Common fold in helix-hairpin-helix proteins
نویسندگان
چکیده
منابع مشابه
Common fold in helix-hairpin-helix proteins.
Helix-hairpin-helix (HhH) is a widespread motif involved in non-sequence-specific DNA binding. The majority of HhH motifs function as DNA-binding modules, however, some of them are used to mediate protein-protein interactions or have acquired enzymatic activity by incorporating catalytic residues (DNA glycosylases). From sequence and structural analysis of HhH-containing proteins we conclude th...
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The helix-loop-helix (HLH) family of transcription factors comprises >200 members, which have been identified in organisms from yeast to man (reviewed in Littlewood and Evan, 1995; Massari and Murre, 2000). In metazoa, HLH proteins function in the coordinate regulation of gene expression, orchestrating cell cycle control, cell lineage commitment and cell differentiation. An essential role has b...
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The aggregation of -helix-rich proteins into -sheet-rich amyloid fibrils is associated with fatal diseases, such as Alzheimer’s disease and prion disease. During an aggregation process, protein secondary structure elements— -helices— undergo conformational changes to -sheets. The fact that proteins with different sequences and structures undergo a similar transition on aggregation suggests that...
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BACKGROUND Basic helix loop helix (bHLH) proteins play a critical role in the differentiation of not only striated muscle cells but also adipocytes, neuron cells and smooth muscle cells. Previous studies have established in vitro mouse mesangial cells (MCs) to maintain the differentiated smooth muscle phenotype. MATERIALS AND METHODS The purpose of the present study was to clone bHLH proteins...
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ژورنال
عنوان ژورنال: Nucleic Acids Research
سال: 2000
ISSN: 1362-4962
DOI: 10.1093/nar/28.14.2643